langendorff constant pressure perfusion system Search Results


constant pressure perfusion langendorff system  (Harvard Bioscience)
90
Harvard Bioscience constant pressure perfusion langendorff system
We characterize calcium transients in ventricular cardiomyocytes in response to drugs, both computationally (top) and experimentally (bottom) and identify the ion channels that most likely generate early afterdepolarizations (left). We then screen the concentration space of the two most relevant channels and identify the classification boundary between the arrhythmic and non-arrhythmic domains using high performance computing and machine learning (center). We validate our approach using electrocardiograms, both computationally and experimentally, in whole heart simulations and isolated <t>Langendorff</t> perfused hearts (right). We demonstrate the potential of our new classifier by risk stratifying 23 common drugs and comparing the result against the reported risk categories of these compounds.
Constant Pressure Perfusion Langendorff System, supplied by Harvard Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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constant pressure perfusion langendorff system - by Bioz Stars, 2026-05
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turnkey langendorff perfusion systems  (ADInstruments)
93
ADInstruments turnkey langendorff perfusion systems
We characterize calcium transients in ventricular cardiomyocytes in response to drugs, both computationally (top) and experimentally (bottom) and identify the ion channels that most likely generate early afterdepolarizations (left). We then screen the concentration space of the two most relevant channels and identify the classification boundary between the arrhythmic and non-arrhythmic domains using high performance computing and machine learning (center). We validate our approach using electrocardiograms, both computationally and experimentally, in whole heart simulations and isolated <t>Langendorff</t> perfused hearts (right). We demonstrate the potential of our new classifier by risk stratifying 23 common drugs and comparing the result against the reported risk categories of these compounds.
Turnkey Langendorff Perfusion Systems, supplied by ADInstruments, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/turnkey langendorff perfusion systems/product/ADInstruments
Average 93 stars, based on 1 article reviews
turnkey langendorff perfusion systems - by Bioz Stars, 2026-05
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constant perfusion pressure apparatus  (ADInstruments)
93
ADInstruments constant perfusion pressure apparatus
We characterize calcium transients in ventricular cardiomyocytes in response to drugs, both computationally (top) and experimentally (bottom) and identify the ion channels that most likely generate early afterdepolarizations (left). We then screen the concentration space of the two most relevant channels and identify the classification boundary between the arrhythmic and non-arrhythmic domains using high performance computing and machine learning (center). We validate our approach using electrocardiograms, both computationally and experimentally, in whole heart simulations and isolated <t>Langendorff</t> perfused hearts (right). We demonstrate the potential of our new classifier by risk stratifying 23 common drugs and comparing the result against the reported risk categories of these compounds.
Constant Perfusion Pressure Apparatus, supplied by ADInstruments, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/constant perfusion pressure apparatus/product/ADInstruments
Average 93 stars, based on 1 article reviews
constant perfusion pressure apparatus - by Bioz Stars, 2026-05
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minipulse 3 peristaltic pump  (Gilson Inc)
90
Gilson Inc minipulse 3 peristaltic pump
We characterize calcium transients in ventricular cardiomyocytes in response to drugs, both computationally (top) and experimentally (bottom) and identify the ion channels that most likely generate early afterdepolarizations (left). We then screen the concentration space of the two most relevant channels and identify the classification boundary between the arrhythmic and non-arrhythmic domains using high performance computing and machine learning (center). We validate our approach using electrocardiograms, both computationally and experimentally, in whole heart simulations and isolated <t>Langendorff</t> perfused hearts (right). We demonstrate the potential of our new classifier by risk stratifying 23 common drugs and comparing the result against the reported risk categories of these compounds.
Minipulse 3 Peristaltic Pump, supplied by Gilson Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/minipulse 3 peristaltic pump/product/Gilson Inc
Average 90 stars, based on 1 article reviews
minipulse 3 peristaltic pump - by Bioz Stars, 2026-05
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sodium pentobarbitone  (Merieux NutriSciences)
90
Merieux NutriSciences sodium pentobarbitone
We characterize calcium transients in ventricular cardiomyocytes in response to drugs, both computationally (top) and experimentally (bottom) and identify the ion channels that most likely generate early afterdepolarizations (left). We then screen the concentration space of the two most relevant channels and identify the classification boundary between the arrhythmic and non-arrhythmic domains using high performance computing and machine learning (center). We validate our approach using electrocardiograms, both computationally and experimentally, in whole heart simulations and isolated <t>Langendorff</t> perfused hearts (right). We demonstrate the potential of our new classifier by risk stratifying 23 common drugs and comparing the result against the reported risk categories of these compounds.
Sodium Pentobarbitone, supplied by Merieux NutriSciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sodium pentobarbitone/product/Merieux NutriSciences
Average 90 stars, based on 1 article reviews
sodium pentobarbitone - by Bioz Stars, 2026-05
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gravity fed, constant-pressure langendorff perfusion system  (Radnoti LLC)
90
Radnoti LLC gravity fed, constant-pressure langendorff perfusion system
We characterize calcium transients in ventricular cardiomyocytes in response to drugs, both computationally (top) and experimentally (bottom) and identify the ion channels that most likely generate early afterdepolarizations (left). We then screen the concentration space of the two most relevant channels and identify the classification boundary between the arrhythmic and non-arrhythmic domains using high performance computing and machine learning (center). We validate our approach using electrocardiograms, both computationally and experimentally, in whole heart simulations and isolated <t>Langendorff</t> perfused hearts (right). We demonstrate the potential of our new classifier by risk stratifying 23 common drugs and comparing the result against the reported risk categories of these compounds.
Gravity Fed, Constant Pressure Langendorff Perfusion System, supplied by Radnoti LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gravity fed, constant-pressure langendorff perfusion system/product/Radnoti LLC
Average 90 stars, based on 1 article reviews
gravity fed, constant-pressure langendorff perfusion system - by Bioz Stars, 2026-05
90/100 stars
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langendorff rat heart preparation langendorff perfusion system  (ADInstruments)
93
ADInstruments langendorff rat heart preparation langendorff perfusion system
We characterize calcium transients in ventricular cardiomyocytes in response to drugs, both computationally (top) and experimentally (bottom) and identify the ion channels that most likely generate early afterdepolarizations (left). We then screen the concentration space of the two most relevant channels and identify the classification boundary between the arrhythmic and non-arrhythmic domains using high performance computing and machine learning (center). We validate our approach using electrocardiograms, both computationally and experimentally, in whole heart simulations and isolated <t>Langendorff</t> perfused hearts (right). We demonstrate the potential of our new classifier by risk stratifying 23 common drugs and comparing the result against the reported risk categories of these compounds.
Langendorff Rat Heart Preparation Langendorff Perfusion System, supplied by ADInstruments, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/langendorff rat heart preparation langendorff perfusion system/product/ADInstruments
Average 93 stars, based on 1 article reviews
langendorff rat heart preparation langendorff perfusion system - by Bioz Stars, 2026-05
93/100 stars
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Image Search Results


We characterize calcium transients in ventricular cardiomyocytes in response to drugs, both computationally (top) and experimentally (bottom) and identify the ion channels that most likely generate early afterdepolarizations (left). We then screen the concentration space of the two most relevant channels and identify the classification boundary between the arrhythmic and non-arrhythmic domains using high performance computing and machine learning (center). We validate our approach using electrocardiograms, both computationally and experimentally, in whole heart simulations and isolated Langendorff perfused hearts (right). We demonstrate the potential of our new classifier by risk stratifying 23 common drugs and comparing the result against the reported risk categories of these compounds.

Journal: bioRxiv

Article Title: Classifying drugs by their arrhythmogenic risk using machine learning

doi: 10.1101/545863

Figure Lengend Snippet: We characterize calcium transients in ventricular cardiomyocytes in response to drugs, both computationally (top) and experimentally (bottom) and identify the ion channels that most likely generate early afterdepolarizations (left). We then screen the concentration space of the two most relevant channels and identify the classification boundary between the arrhythmic and non-arrhythmic domains using high performance computing and machine learning (center). We validate our approach using electrocardiograms, both computationally and experimentally, in whole heart simulations and isolated Langendorff perfused hearts (right). We demonstrate the potential of our new classifier by risk stratifying 23 common drugs and comparing the result against the reported risk categories of these compounds.

Article Snippet: We excised the hearts from anesthetized rats (2.5% isoflurane in 95% oxygen and 5% carbon dioxide), immediately cannulated the aorta, connected it to a constant pressure perfusion Langendorff system (Harvard Apparatus, Massachusetts) with Krebs solution (118mM NaCl, 4.75mM KCl, 25mM NaHCO 3 , 1.2mM KH 2 PO 4 , 1.2mM MgSO 4 , 1.5mM CaCl 2 , 11mM glucose, and 2mM Pyruvate), warmed to 37° C, and bubbled with 95% oxygen and 5% carbon dioxide.

Techniques: Concentration Assay, Isolation